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Essentially, L-DOPA is transported across the blood brain barrier by LAT-1 (L or Large amino acid transporter). This transporter moves amino acids like phenylalanine and tyrosine across the blood brain barrier. Without a transporter, a molecule needs to be lipid soluble to cross the blood brain barrier.
Sinemet is a combination of two ingredients such as carbidopa and levodopa. It alleviates symptoms of Parkinson's disease such as hypokinesia, stiffness, tremor, dysphagia, salivary discharge. Sinemet is a combination of carbidopa and levodopa applied in treatment of Parkinson's disease and Dopa-Responsive Dystonia. It prevents hypokinesia, stiffness, tremor, dysphagia, salivary discharge. Levodopa converts into dopamine owing to DOPA decarboxylase enzyme. Activation of central dopamine receptors improves the symptoms of Parkinson's disease and combination of carbidora reduces the unwanted peripheral side-effects of levodopa. Carbidopa usage increases the quantity of levodopa in the bloodstream that is available to enter the brain.
Use Sinemet Cr exactly as prescribed by your doctor. Do not take more of this drug than is recommended. Take this medication with a full glass of water with or without food at the same time every day. Your doctor may occasionally change your dose to make sure you get the best results from this medication.
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If you are taking any of these drugs: Reserpine or tetrabenazine. If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking this medicine within 14 days of those drugs can cause very bad high blood pressure. If you are taking another drug that has the same drug in it. This is not a list of all drugs or health problems that interact with Sinemet.
Use Sinemet Cr exactly as prescribed by your doctor. Do not take more of this drug than is recommended. Take this medication with a full glass of water with or without food at the same time every day. Your doctor may occasionally change your dose to make sure you get the best results from this medication.
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