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The mechanism of action of 5FC relies solely on conversion to 5FU. Inactive 5FC is enzymatically transported into the fungal cell, where cytosine deaminase converts 5FC to 5FU. 5FU appears to exert two mechanisms of action, the first one being the conversion of 5FU to fluorouridine monophosphate to fluorouridine diphosphate into active fluorouridine triphosphate FUTP. FUTP inhibits protein synthesis by replacing uridylic acid in RNA. Incorporation into the RNA sequence ultimately disrupts transfer RNA and protein synthesis. The second mechanism pertains to 5FU conversion to fluorodeoxyuridine monophosphate, which inhibits DNA synthesis by thymidylate.
The patients most likely to respond to the drug had socalled PDL1 positive tumors, indicating that this biomarker might help identify patients who would be good candidates for this therapy.

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Pero George aadi que es particularmente complejo cuando unos adultos ms jvenes, en medio de sus carreras, funcionando como fuentes de ingresos y cuidadores, pueden sufrir una discapacidad que afecte a sus vidas y las vidas de sus familiares y seres queridos.
However, enterococci can cause dangerous infections in other parts of the body like the urinary tract, the bloodstream, a wound or a catheter insertion site if it travels to them.