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Arava contains active substance Leflunomide. Its active metabolite is A771726 inhibits dihydroorotate dehydrogenase and has antiproliferative effects. A771726 in vitro inhibits proliferation and DNA synthesis of T-lymphocytes induced by mitogen. A771726 selectively binds to dihydroorotate dehydrogenase and inhibits it and hereby G1 stage of lymphocytes proliferation. Lymphocyte proliferation is one of the crucial stages in the development of rheumatoid arthritis. Arava is used to treat rheumatoid arthritis and reduces inflammation in the joints.
Tell your doctor immediately if signs of infection (such as fever), extreme weakness/fatigue or easy bruising/bleeding develop. Leflunomide may need to be stopped. The elimination procedure using cholestyramine or charcoal may be required. Consult your doctor for more details. Leflunomide has rarely caused serious (possibly fatal) liver disease, especially in people with other risks for liver disease.

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