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Missed dose. Take the missed dose as soon as you remember, but at least 2 hours since your last meal. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Precautions. Nexavar can cause heart problems. Stop taking this medicine and call your doctor at once if you have chest pain and severe dizziness, fainting, sweating, or feeling short of breath. Nexavar can also cause severe bleeding. Call your doctor if you have blood in your urine or stools, abnormal vaginal bleeding, severe stomach pain, coughing up blood, or any bleeding that will not stop. Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose. To lower the chance of getting cut, bruised or injured, use caution with sharp objects like safety razors and nail cutters, and avoid activities such as contact sports. Women who are pregnant must not take this medication as it can be absorbed through the skin and lungs and may harm an unborn baby.
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Drug interactions. The medications that may interact with Nexavar are dexamethasone, neomycin, St. John's wort, a blood thinner such as Warfarin, Coumadin, seizure medication such as carbamazepine, fosphenytoin, phenobarbital, phenytoin or tuberculosis medicine such as rifabutin, rifampin.
Directions. Read the Patient Information Leaflet provided by your pharmacist before you start using sorafenib. Take this medication by mouth on an empty stomach (at least 1 hour before or 2 hours after a meal) as directed by your doctor, usually twice a day. Do not chew or crush the tablets. Swallow tablets whole with a full glass of water.
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