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Digoxin, if it is effective, has some unique advantages compared with the existing heart failure medications. Provided toxicity is avoided, digoxin is remarkably free of side effects. Unlike other interventions for heart failure, except cardiac resynchronisation therapy,8 digoxin increases systolic blood pressure. It is extracted from the leaves of a plant called digitalis lanata. Digoxin increases the force of contraction of the muscle of the heart by inhibiting the activity of an enzyme (ATPase) that controls movement of calcium, sodium, and potassium into heart muscle. Calcium controls the force of contraction.
Directions. Take Lanoxin exactly as prescribed by your doctor. Take it with a full glass of water. Take the medication at the same time every day. Keep taking Lanoxin as directed, even if you feel well. The usual starting dose is 0.0625-0.25 mg daily depending on age and kidney function. The dose may be increased every two weeks to achieve the desired response.
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